- Progressive physical exercise plus sertraline anti-depressant therapy achieves higher rates of depression remission than non-progressive therapy plus sertraline, or sertraline alone in primary care patients with late-life major depression.
- 121 primary care patients were randomized to receive 24 weeks of higher intensity progressive physical exercise plus sertraline, lower intensity non-progressive exercise plus sertraline, or sertraline alone.
- The primary outcome was remission, a score of ≤10 on the Hamilton Rating Scale for Depression.
- 81% in the progressive exercise group achieved remission.
- 73% in the non-progressive exercise group achieved remission.
- 45% in the sertraline only group achieved remission.
- Patients in the progressive exercise group achieved remission in a shorter time than the sertraline only group.